Nandrolone Decanoate
(Intramuscular Injection 200mg/ml)
Description
Each ml contains Nandrolone Decanoate 2OOmg in Ethyl oleate Q.S and 0.9% Benzyl Alcohol - clear, yellowish oily solution. Its empirical formula is C20H44O3 and molecular weight is 428.7
Pharmacological classification
Anabolic Steroids
Pharmacological action
Nandrolone Decanoate has both androgenic and anabolic properties when administered parentally Nandrolone Decanoate is gradually released from the intramuscular depot and subsequently hydrolyzed into Nandrolone.
Indications
1) Nandrolone Decanoate is indicated in the treatment of anemia associated with renal insufficiency. 2) Certain cases of disseminated breast cancer in post-menopausal women and women without ovaries. 3) Osteoporosis due to androgen deficiency in hypogonadal males.
Contra-indications
-Contraindicated in infant, pregnancy & lactating mothers. -Carcinoma of prostate and carcinoma of male breast. -Contraindicated in nephrosis or the nephrotic phase of nephritis, cardiac and renal failure, hypercalcaemia, oedema, jaundice, liver disease with impaired bilirubin excretion, testicular and hepatic carcinoma. Nandrolone Decanoate is not intended for use in female patients other than those with disseminated breast cancer.
Dosage and directions for use
Nandrolone Decanoate injections should be administered intramuscularly, preferably deep into the gluteal muscle. When using Nandrolone Decanoate injections, an adequate iron intake is required for maximum response. If any solid matters separate out, it should be redissolved by warming before use. Adults Females: intramuscular, 50 to 100 mg given every one to four week. Males: intramuscular, 50 to 200 mg given every one to four week Note: When given at three to four week intervals, therapy may be continued for up to 12 weeks. If necessary, cycle may be repeated if second course is preceded by a four-week rest period. Children Children up to 2 years of age: Dosage might be determined by the physician. Children 2 to 13 years of age: Intramuscular, 25 to 50 mg every three to four weeks.
Side effects
Oedema, cholestatic jaundice, hepatic carcinoma, Gynaecomastia, Precocious puberty & shortening of stature due to early closure of epiphysis. Rashes, cramps, dyspepsia. Virilisation which appears in sensitive women as hoarsenses, acne, hirsutism, and increased libido and menstrual irregularities.
Precautions
Patients with the following conditions should be monitored: -In cardiac failure, renal dysfunction, hypertension, epilepsy or migraine (or a history of these conditions), since anabolic steroids may induce salt and fluid retention. -Diabetes : Anabolic steroids may improve the glucose tolerance and decrease the need for insulin or other antidiabetic drugs. -Incomplete statural growth : Anabolic steroids in high dosages may accelerate epiphyseal closure -Skeletal metastases : Anabolic steroids may induce hypercalcemia and hypercalciuria in these patients. -Liver dysfunction. -If signs of virilization develop, treatment should be discontinued
Drug interactions
-Potentiates corticosteroids -Potentiates oral anticoagulants thereby enhancing bleeding tendency. -Liver-enzyme-inducing agents may reduce the effects of Nandrolone Decanoate by enhancing its metabolism in theliver -Reducing efficacy of cyclophosphamide in advanced breast cancer.
Overdosage
Overdoses are not frequent as physician or other expert administers it. Acute intramuscular toxicity of nandrolone is very low.
Preservation
Keep out of the reach and sight of children. Do not store above 30°C. Keep in the original package or container supplied. Do not use this product after the expiry date that is stated in the outer package. The expiry date refers to the last day of the month. Medicines should not be disposed of via wastewater or household waste. Ask your pharmacist how to dispose of medicines no longer required. These measures will help to protect the environment.
Presentation
5 ampoules are packed in a plastic tray. 2 such trays are packed in carton box. All pack sizes may not be marketed.